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Gene expression profiling by microarray analysis reveals an important role for caspase‐1 in dengue virus‐induced p53‐mediated apoptosis

20 Apr 2009

Abstract excerpt

Recently, a dengue virus-induced apoptosis p53- and mitochondria-mediated were reported in human and animal cells. To understand further the underlying mechanisms, a p53-deficient cell line, H1299, and a p53-knockin cell line, H273, were infected with dengue type 1 virus and the cellular gene expression profiles at the mRNA level were analyzed by affymetrix array analysis. The results showed 183 genes with at...

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PMID: 19382257
DOI: 10.1002/jmv.21486

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