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Article

Induction of ID2 Expression by Hypoxia-inducible Factor-1

14 Jul 2004

Abstract excerpt

ID (inhibitor of differentiation/DNA binding) proteins, frequently deregulated in advanced human malignancies, can participate in multiple fundamental traits of cancer, such as block of differentiation, increased proliferation, tissue invasiveness, and angiogenesis. We have previously demonstrated that hypoxia decreases expression of neuronal marker genes in neuroblastoma, but induces genes expressed in the...

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PMID: 15252039
DOI: 10.1074/jbc.m402904200

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