Article
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 2002
Jögi Annika, Øra Ingrid, Nilsson Helén, Lindeheim Asa, Makino Yuichi, Poellinger Lorenz, Axelson Håkan, Påhlman Sven
Abstract excerpt
Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels. Moreover, mouse gene disruption studies have implicated HIF-2 alpha in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic nervous system. Neuroblastoma tumors...
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