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Article

Inhibition studies of sulfonamide-containing folate analogs in yeast.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2003

Patel Onisha, Satchell Jacqueline, Baell Jonathan, Fernley Ross, Coloe Peter, Macreadie Ian

Abstract excerpt

In the folate biosynthetic pathway, sulfa drugs (sulfonamides and sulfones) compete with the natural substrate, para-aminobenzoate (pABA) causing depletion of dihydrofolate (DHF) and subsequent growth inhibition. The sulfa drugs condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate (DHPPP) forming sulfa-dihydropteroate (sulfa-DHP). Here evidence is presented using yeast that such...

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Source

Identifiers

PMID: 12820798
DOI: 10.1089/107662903765826723

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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