Article
Characterization of a mutationally altered dihydropteroate synthase contributing to sulfathiazole resistance in Escherichia coli.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1998
Vedantam G, Nichols B P
Abstract excerpt
A series of Escherichia coli strains were selected for increasing resistance to sulfathiazole. Resistance occurred in seven increments, suggesting the accumulation of several mutations that contributed to overall sulfathiazole resistance. All of the resistant strains had a sulfathiazole-resistant...
Topics
- 4-Aminobenzoic Acid
- Alleles
- Dihydropteroate Synthase
- Drug Resistance, Microbial
- Escherichia coli
- Gene Dosage
- Genes, Bacterial
- Humans
- Kinetics
- Microbial Sensitivity Tests
- Mutation
- Polymerase Chain Reaction
- Sequence Analysis, DNA
- Sulfathiazoles