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Article

Characterization of a mutationally altered dihydropteroate synthase contributing to sulfathiazole resistance in Escherichia coli.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1998

Vedantam G, Nichols B P

Abstract excerpt

A series of Escherichia coli strains were selected for increasing resistance to sulfathiazole. Resistance occurred in seven increments, suggesting the accumulation of several mutations that contributed to overall sulfathiazole resistance. All of the resistant strains had a sulfathiazole-resistant dihydropteroate synthase with a Pro to Ser substitution at amino acid position 64. Overproduction of the wild-type...

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Identifiers

PMID: 9650994
DOI: 10.1089/mdr.1998.4.91

Genes

DHPS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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