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Article

Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathway.

Cell cycle (Georgetown, Tex.) - 1 Oct 2004

De Smaele Enrico, Di Marcotullio Lucia, Ferretti Elisabetta, Screpanti Isabella, Alesse Edoardo, Gulino Alberto

Abstract excerpt

Although deregulation of Hedgehog signalling is considered to play a crucial oncogenic role and commonly occurrs in medulloblastoma, genetic lesions in components of this pathway are observed in a minority of cases. The recent identification of a novel putative tumor suppressor (REN(KCTD11)) on chromosome 17p13.2, a region most frequently lost in human medulloblastoma, highlights the role of allelic deletion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15467454
DOI: 10.4161/cc.3.10.1200

Genes

KCTD11
REN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathway.PMID 15467454Read ↗

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