Article
Screening for novel ENU-induced rhythm, entrainment and activity mutants.
Genes, brain, and behavior - 1 Aug 2004
Bacon Y, Ooi A, Kerr S, Shaw-Andrews L, Winchester L, Breeds S, Tymoska-Lalanne Z, Clay J, Greenfield A G, Nolan P M
Abstract excerpt
Chemical mutagenesis has provided an opportunity to develop and expand the repertoire of behavioural mutants for gene function studies. With this in mind, we have established a screen in mice for mutations affecting circadian rhythms, entrainment to light and other wheel-running parameters. The screen consists of an assessment of mouse wheel-running activity in a 12:12 h light/dark cycle for 7-10 days followed by...
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