Article
The proinflammatory phenotype of senescent cells: the p53-mediated ICAM-1 expression.
Annals of the New York Academy of Sciences - 1 Jun 2004
Kletsas Dimitris, Pratsinis Harris, Mariatos Giorgos, Zacharatos Panayotis, Gorgoulis Vassilis G
Abstract excerpt
Senescent cells are characterized by the activation of the tumor suppressor protein p53 and consequently their inability to proliferate. However, their phenotype is not restricted to the exhaustion of their replicative potential, as they also exhibit a proinflammatory phenotype, which could possibly contribute to the aging process. Intercellular adhesion molecule-1 (ICAM-1) is one of the molecules involved in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.