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Article

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.

Cancer immunology, immunotherapy : CII - 1 Dec 2009

Salvioli Stefano, Capri Miriam, Bucci Laura, Lanni Cristina, Racchi Marco, Uberti Daniela, Memo Maurizio, Mari Daniela, Govoni Stefano, Franceschi Claudio

Abstract excerpt

BACKGROUND: Centenarians are exceptionally long living individuals who escaped the most common age-related diseases. In particular they appear to be effectively protected from cancers. The mechanisms that underlie this protection are quite complex and still largely unclear. AIM: To critically analyse the literature in order to propose a unifying hypothesis that can account for this cancer protection in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19139887
DOI: 10.1007/s00262-008-0639-6
PMCID: PMC11030834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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