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Article

Expression of a K48R mutant ubiquitin protects mouse testis from cryptorchid injury and aging.

The American journal of pathology - 1 Dec 2003

Rasoulpour Reza J, Schoenfeld Heidi A, Gray Douglas A, Boekelheide Kim

Abstract excerpt

Testis injury models can be useful for determining the in vivo function of genes. In this study, ubiquitin, a tag for 26S-proteasome degradation, was mutated at lysine 48 (K48R) to inhibit ubiquitin chain assembly. K48R transgenic mice had testes with delayed germ cell loss following the acute injury of experimental cryptorchidism, and were resistant to the chronic injury of aging-associated testicular atrophy....

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Identifiers

PMID: 14633631
DOI: 10.1016/S0002-9440(10)63614-0
PMCID: PMC1892386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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