Article
Differential regulation of telomerase in endothelial cells by fibroblast growth factor-2 and vascular endothelial growth factor-a: association with replicative life span.
Annals of the New York Academy of Sciences - 1 Jun 2004
Trivier Elisabeth, Kurz David J, Hong Ying, Huang Hsiu-Lin, Erusalimsky Jorge D
Abstract excerpt
In cultured human umbilical vein endothelial cells (HUVECs), fibroblast growth factor-2 (FGF-2), but not vascular endothelial growth factor-A (VEGF-A), upregulates telomerase activity. Here, we examined the functional significance of this differential regulation on the replicative life span of HUVECs. HUVECs were serially passaged until senescence under four different conditions: (1) EGM-2, a medium containing...
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