Article
Stochastic simulations suggest that HIV-1 survives close to its error threshold.
PLoS computational biology - 1 Jan 2012
Tripathi Kushal, Balagam Rajesh, Vishnoi Nisheeth K, Dixit Narendra M
Abstract excerpt
The use of mutagenic drugs to drive HIV-1 past its error threshold presents a novel intervention strategy, as suggested by the quasispecies theory, that may be less susceptible to failure via viral mutation-induced emergence of drug resistance than current strategies. The error threshold of HIV-1, μ c, however, is not known. Application of the quasispecies theory to determine μ c poses significant challenges:...
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