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Article

Vancomycin-induced deletion of the methicillin resistance gene mecA in Staphylococcus aureus.

The Journal of antimicrobial chemotherapy - 1 Aug 2004

Adhikari Rajan P, Scales Georgina C, Kobayashi Kere, Smith John M B, Berger-Bächi Brigitte, Cook Gregory M

Abstract excerpt

OBJECTIVE: To elucidate factors that contribute to the development of vancomycin resistance in methicillin-resistant Staphylococcus aureus (MRSA). METHODS: Forty-nine MRSA isolates were subjected to passage selection with vancomycin to isolate mutants with reduced susceptibility to vancomycin. One mutant was chosen for detailed molecular and biochemical characterization. RESULTS: Five vancomycin-resistant mutants...

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Identifiers

PMID: 15243027
DOI: 10.1093/jac/dkh350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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