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Article

A potential role of transposon IS431 in the loss of mecA gene.

Scientific reports - 25 Jan 2017

Wang Aihua, Zhou Kai, Liu Yang, Yang Liang, Zhang Qin, Guan Jing, Zhong Nanshan, Zhuo Chao

Abstract excerpt

Acquisition of a vancomycin-resistance-determinant may trigger deletion of the mecA gene. However, the molecular mechanisms involved remain largely unknown. In this study, we successfully produced vancomycin-intermediate-resistant Staphylococcus aureus (VISA) from Methicillin-resistant-S. aureus (MRSA) through serial passages with vancomycin. Five MRSA isolates achieved a vancomycin MIC of >8 mg/ml after 45-day...

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Share to Chromosomes, Bacterial
Share to Colony Count, Microbial
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Pulsed-Field

Share to Methicillin-Resistant Staphylococcus aureus

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Source

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Identifiers

PMID: 28120911
DOI: 10.1038/srep41237
PMCID: PMC5264636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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