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Article

RNAi of COL1A1 in mesenchymal progenitor cells.

European journal of human genetics : EJHG - 1 Oct 2004

Millington-Ward Sophia, McMahon Helena P, Allen Danny, Tuohy Gearóid, Kiang Anna-Sophia, Palfi Arpad, Kenna Paul F, Humphries Peter, Farrar G Jane

Abstract excerpt

Given that mutant COL1A1 is known to cause Osteogenesis Imperfecta (OI), tools to modulate COL1A1 expression are likely to be of significant therapeutic value. In this context, we have evaluated RNA interference (RNAi) as a means to downregulate COL1A1 expression in Cos-7 cells and in human mesenchymal progenitor stem cells (MPCs), the latter cells giving rise to bone and therefore representing a target cell type...

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Source

Identifiers

PMID: 15241481
DOI: 10.1038/sj.ejhg.5201230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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