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Article

Allele-specific gene silencing in osteogenesis imperfecta.

Endocrine development - 1 Jan 2011

Ljunggren Östen, Lindahl Katarina, Rubin Carl-Johan, Kindmark Andreas

Abstract excerpt

OI is caused by mutations in the genes encoding for collagen type I COL1A1 and COL1A2, respectively. The patients suffer from bone fragility, and the severity can range from mild, with fractures in the youth, to lethal forms. Today, there is no effective treatment for the disorder. OI is caused by dominant negative mutations. A tempting approach to treat the disease would be to silence the allele carrying the...

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Identifiers

PMID: 21865757
DOI: 10.1159/000328133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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