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Article

Gene targeting in stem cells from individuals with osteogenesis imperfecta.

Science (New York, N.Y.) - 20 Feb 2004

Chamberlain Joel R, Schwarze Ulrike, Wang Pei-Rong, Hirata Roli K, Hankenson Kurt D, Pace James M, Underwood Robert A, Song Kit M, Sussman Michael, Byers Peter H, Russell David W

Abstract excerpt

Adult stem cells offer the potential to treat many diseases through a combination of ex vivo genetic manipulation and autologous transplantation. Mesenchymal stem cells (MSCs, also referred to as marrow stromal cells) are adult stem cells that can be isolated as proliferating, adherent cells from bones. MSCs can differentiate into multiple cell types present in several tissues, including bone, fat, cartilage, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14976317
DOI: 10.1126/science.1088757

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Related research

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Research trail→

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Gene targeting in stem cells from individuals with osteogenesis imperfecta.PMID 14976317Read ↗

Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta.Semantic proximity Read ↗

Normal Collagen and Bone Production by Gene-targeted Human Osteogenesis Imperfecta iPSCsSemantic proximity Read ↗

AAV-based gene editing of type 1 collagen mutation to treat osteogenesis imperfectaSemantic proximity Read ↗

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Modification of COL1A1 in Autologous Adipose Tissue-Derived Progenitor Cells Rescues the Bone Phenotype in a Mouse Model of Osteogenesis Imperfecta.Semantic proximity Read ↗

Restoration of Osteogenesis by CRISPR/Cas9 Genome Editing of the Mutated COL1A1 Gene in Osteogenesis ImperfectaSemantic proximity Read ↗

Generation of a patient-specific induced pluripotent stem cell line, KSCBi006-A, for osteogenesis imperfecta type I with the COL1A1, c.3162delT mutation.Semantic proximity Read ↗

Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans.Semantic proximity Read ↗

Allele-specific gene silencing in osteogenesis imperfecta.Semantic proximity Read ↗

Identification of a Family with van der Hoeve's syndrome Harboring a Novel COL1A1 Mutation and Generation of Patient-Derived iPSC Lines and CRISPR/Cas9-Corrected Isogenic iPSCsSemantic proximity Read ↗

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug ScreeningSemantic proximity Read ↗

An iMSC-Based iPSC Model for Osteogenesis Imperfecta: A Platform for Disease Modeling and Drug ScreeningSemantic proximity Read ↗

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