Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer.

doi:10.1002/mc.20107

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Article

Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer.

Molecular carcinogenesis - 1 Aug 2005

Lewis Anne M, Ough Matthew, Hinkhouse Marilyn M, Tsao Ming-Sound, Oberley Larry W, Cullen Joseph J

Abstract excerpt

NAD(P)H:quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation of reactive oxygen species (ROS). The aim of our study was to determine if NQO1 is elevated in pancreatic cancer specimens and pancreatic cancer cell lines and if so, would compounds previously demonstrated to redox cycle with NQO1 be effective in killing...

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Identifiers

PMID: 16003741
DOI: 10.1002/mc.20107
PMCID: PMC7262682

Genes

NQO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.