Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.

Human molecular genetics - 1 Sept 2004

Sawcer Stephen J, Maranian Mel, Singlehurst Sara, Yeo TaiWai, Compston Alastair, Daly Mark J, De Jager Philip L, Gabriel Stacey, Hafler David A, Ivinson Adrian J, Lander Eric S, Rioux John D, Walsh Emily, Gregory Simon G, Schmidt Silke, Pericak-Vance Margaret A, Barcellos Lisa, Hauser Stephen L, Oksenberg Jorge R, Kenealy Shannon J, Haines Jonathan L

Abstract excerpt

To explore the potential value of recently developed high-density linkage mapping methods in the analysis of complex disease we have regenotyped five nuclear families first studied in the 1996 UK multiple sclerosis linkage genome screen, using Applied Biosystems high-density microsatellite linkage mapping set, the Illumina BeadArray linkage mapping panel (version 3) and the Affymetrix GeneChip Human Mapping 10K...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Evaluation Studies as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Genotype

Share to Microsatellite Repeats

Share to Multiple Sclerosis

Share to Polymorphism, Single Nucleotide

Share to United Kingdom

Source

Identifiers

PMID: 15238506
DOI: 10.1093/hmg/ddh202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.PMID 15238506Read ↗

A high-density screen for linkage in multiple sclerosis.Semantic proximity Read ↗

Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis.Semantic proximity Read ↗

Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies.Semantic proximity Read ↗

Linkage analysis of the GAW14 simulated dataset with microsatellite and single-nucleotide polymorphism markers in large pedigrees.Semantic proximity Read ↗

Refining the analysis of a whole genome linkage disequilibrium association map: the United Kingdom results.Semantic proximity Read ↗

Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis.Semantic proximity Read ↗

Efficiency and consistency of haplotype tagging of dense SNP maps in multiple samples.Semantic proximity Read ↗

Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits.Semantic proximity Read ↗

Identification by denaturing high-performance liquid chromatography of numerous polymorphisms in a candidate region for multiple sclerosis susceptibility.Semantic proximity Read ↗

Evaluating the results of genomewide linkage scans of complex traits by locus counting.Semantic proximity Read ↗

The value of regenotyping older linkage data sets with denser marker panels.Semantic proximity Read ↗

Evaluation of linkage disequilibrium and its effect on non-parametric multipoint linkage analysis using two high density single-nucleotide polymorphism mapping panels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.