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Article

Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP.

American journal of physiology. Cell physiology - 1 Aug 2004

Hogarth D Kyle, Sandbo Nathan, Taurin Sebastien, Kolenko Vladimir, Miano Joseph M, Dulin Nickolai O

Abstract excerpt

Extracellular ATP is released from activated platelets and endothelial cells and stimulates proliferation of vascular smooth muscle cells (VSMC). We found that ATP stimulates a profound but transient activation of protein kinase A (PKA) via purinergic P2Y receptors. The specific inhibition of PKA by adenovirus-mediated transduction of the PKA inhibitor (PKI) attenuates VSMC proliferation in response to ATP,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Share to Receptors, Purinergic P2

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Source

Identifiers

PMID: 15238360
DOI: 10.1152/ajpcell.00547.2003

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SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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