Article
Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulation in the LQT1 form of congenital long QT syndrome: multicenter study in Japan.
Journal of the American College of Cardiology - 7 Jul 2004
Shimizu Wataru, Horie Minoru, Ohno Seiko, Takenaka Kotoe, Yamaguchi Masato, Shimizu Masami, Washizuka Takashi, Aizawa Yoshifusa, Nakamura Kazufumi, Ohe Tohru, Aiba Takeshi, Miyamoto Yoshihiro, Yoshimasa Yasunao, Towbin Jeffrey A, Priori Silvia G, Kamakura Shiro
Abstract excerpt
OBJECTIVES: We sought to compare the arrhythmic risk and sensitivity to sympathetic stimulation of mutations located in transmembrane regions and C-terminal regions of the KCNQ1 channel in the LQT1 form of congenital long QT syndrome (LQTS). BACKGROUND: The LQT1 syndrome is frequently manifested with variable expressivity and incomplete penetrance and is much more sensitive to sympathetic stimulation than the...
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