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Article

Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome.

Heart rhythm - 1 Jun 2012

Costa Jason, Lopes Coeli M, Barsheshet Alon, Moss Arthur J, Migdalovich Dmitriy, Ouellet Gregory, McNitt Scott, Polonsky Slava, Robinson Jennifer L, Zareba Wojciech, Ackerman Michael J, Benhorin Jesaia, Kaufman Elizabeth S, Platonov Pyotr G, Shimizu Wataru, Towbin Jeffrey A, Vincent G Michael, Wilde Arthur A M, Goldenberg Ilan

Abstract excerpt

BACKGROUND: Men and women with type 1 long QT syndrome (LQT1) exhibit time-dependent differences in the risk for cardiac events. OBJECTIVE: We hypothesized that sex-specific risk for LQT1 is related to the location and function of the disease-causing mutation in the KCNQ1 gene. METHODS: The risk for life-threatening cardiac events (comprising aborted cardiac arrest [ACA] or sudden cardiac death [SCD]) from birth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22293141
DOI: 10.1016/j.hrthm.2012.01.020
PMCID: PMC3358462

Genes

SCD
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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