Article
The receptor protein tyrosine phosphatase CLR-1 is required for synaptic partner recognition.
PLoS genetics - 1 May 2018
Varshney Aruna, Benedetti Kelli, Watters Katherine, Shankar Raakhee, Tatarakis David, Coto Villa Doris, Magallanes Khristina, Agenor Venia, Wung William, Farah Fatima, Ali Nebat, Le Nghi, Pyle Jacqueline, Farooqi Amber, Kieu Zanett, Bremer Martina, VanHoven Miri
Abstract excerpt
During neural circuit formation, most axons are guided to complex environments, coming into contact with multiple potential synaptic partners. However, it is critical that they recognize specific neurons with which to form synapses. Here, we utilize the split GFP-based marker Neuroligin-1 GFP Reconstitution Across Synaptic Partners (NLG-1 GRASP) to visualize specific synapses in live animals, and a...
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