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Article

Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.

Cancer research - 1 Jul 2004

Tian Fang, Byfield Stacey DaCosta, Parks W Tony, Stuelten Christina H, Nemani Deepa, Zhang Ying E, Roberts Anita B

Abstract excerpt

The role of transforming growth factor beta (TGF-beta) in carcinogenesis is complex, with tumor suppressor and pro-oncogenic activities depending on the particular tumor cell and its stage in malignant progression. We previously have demonstrated in breast cancer cell lines that Smad2/3 signaling played a dominant role in mediating tumor suppressor effects on well-differentiated breast cancer cell lines grown as...

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Identifiers

PMID: 15231662
DOI: 10.1158/0008-5472.CAN-04-0030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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