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Article

Formation of human hepatocytes by human hematopoietic stem cells in sheep.

Blood - 15 Oct 2004

Almeida-Porada Graça, Porada Christopher D, Chamberlain Jason, Torabi Ali, Zanjani Esmail D

Abstract excerpt

We took advantage of the proliferative and permissive environment of the developing preimmune fetus to develop a noninjury large animal model in sheep, in which the transplantation of defined populations of human hematopoietic stem cells resulted in the establishment of human hematopoiesis and led to the formation of significant numbers of long-lasting, functional human liver cells, with some animals exhibiting...

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Identifiers

PMID: 15231580
DOI: 10.1182/blood-2004-01-0259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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