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Persistence of functional hepatocyte-like cells in immune-compromised mice

10 Dec 2010

Abstract excerpt

BACKGROUND: Human embryonic stem cells (hESCs) can be efficiently differentiated to hepatocyte-like cells (HLCs) in vitro and demonstrate many of the functions and gene expression found in the adult liver. AIMS: In this study, we assess the therapeutic value of HLCs in long-term cell-based therapies in vivo. METHODS: hESC-derived HLCs were injected into the spleen of acutely injured NODscid(IL-2Rγ) null mice and...

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PMID: 21143581
DOI: 10.1111/j.1478-3231.2010.02414.x

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