Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CA1 hippocampal neuronal loss in familial Alzheimer's disease presenilin-1 E280A mutation is related to epilepsy.

Epilepsia - 1 Jul 2004

Velez-Pardo Carlos, Arellano Jon I, Cardona-Gomez Patricia, Jimenez Del Rio Marlene, Lopera Francisco, De Felipe Javier

Abstract excerpt

PURPOSE: Alzheimer disease (AD) and epilepsy are brain disorders frequently associated with neuronal cell loss in mesial temporal lobe structures, but presenting different patterns of damage. Recently it was proposed that a causal relation may exist between AD pathology and the appearance of epilepsy in some cases with AD. This study aimed to determine the neuronal loss in CA1 hippocampal region from patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Cell Death

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Comorbidity

Share to Hippocampus

Share to Neurofibrillary Tangles

Share to Plaque, Amyloid

Share to Presenilin-1

Share to Pyramidal Cells

Source

Identifiers

PMID: 15230697
DOI: 10.1111/j.0013-9580.2004.55403.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CA1 hippocampal neuronal loss in familial Alzheimer's disease presenilin-1 E280A mutation is related to epilepsy.PMID 15230697Read ↗

Epileptic seizures in autosomal dominant forms of Alzheimer's disease.Semantic proximity Read ↗

Epileptic seizures in AD patients.Semantic proximity Read ↗

A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation.Semantic proximity Read ↗

Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s diseaseSemantic proximity Read ↗

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologicallySemantic proximity Read ↗

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 BlockadeSemantic proximity Read ↗

[Image characterization of Alzheimer's disease associated with the E280A-PS1 mutation. Case-control study: MRI findings].Semantic proximity Read ↗

Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer's Disease Detected Using Quantitative Electroencephalography.Semantic proximity Read ↗

A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death.Semantic proximity Read ↗

Pyramidal Nerve Cell Loss in Alzheimer's DiseaseSemantic proximity Read ↗

Age-dependent concomitant changes in synaptic dysfunction and GABAergic pathway in the APP/PS1 mouse model.Semantic proximity Read ↗

Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.