Article
Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer's Disease Detected Using Quantitative Electroencephalography.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Ochoa John Fredy, Alonso Joan Francesc, Duque Jon Edinson, Tobón Carlos Andrés, Baena Ana, Lopera Francisco, Mañanas Miguel Angel, Hernández Alher Mauricio
Abstract excerpt
BACKGROUND: Presenilin-1 (PSEN1) mutations are the most common cause of familial early onset Alzheimer's disease (AD). The PSEN1 E280A (E280A) mutation has an autosomal dominant inheritance and is involved in the production of amyloid-β. The largest family group of carriers with E280A mutation is found in Antioquia, Colombia. The study of mutation carriers provides a unique opportunity to identify brain changes...
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