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Article

Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence.

Behavior genetics - 1 Mar 2007

Dick Danielle M, Aliev Fazil, Kramer John, Wang Jen C, Hinrichs Anthony, Bertelsen Sarah, Kuperman Sam, Schuckit Marc, Nurnberger John, Edenberg Howard J, Porjesz Bernice, Begleiter Henri, Hesselbrock Victor, Goate Alison, Bierut Laura

Abstract excerpt

The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be...

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Source

Identifiers

PMID: 17160701
DOI: 10.1007/s10519-006-9131-2

Genes

CHRM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence.PMID 17160701Read ↗

Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families.Semantic proximity Read ↗

Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.Semantic proximity Read ↗

NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies.Semantic proximity Read ↗

Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.Semantic proximity Read ↗

CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study.Semantic proximity Read ↗

No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples.Semantic proximity Read ↗

Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition.Semantic proximity Read ↗

Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.Semantic proximity Read ↗

Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample.Semantic proximity Read ↗

A cholinergic receptor gene (CHRM2) affects event-related oscillations.Semantic proximity Read ↗

Genes positively regulated by Mef2c in cortical neurons are enriched for common genetic variation associated with IQ and educational attainment.Semantic proximity Read ↗

CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness.Semantic proximity Read ↗

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