Article
Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse.
Molecular and cellular endocrinology - 30 Jun 2004
Fukuzawa Noriho H, Ohsako Seiichiroh, Wu Qing, Sakaue Motoharu, Fujii-Kuriyama Yoshiaki, Baba Tadashi, Tohyama Chiharu
Abstract excerpt
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in adult animals has been reported to perturb the regulation of steroidogenesis in the testis, possibly by arylhydrocarbon receptor (AhR). To clarify how AhR is involved in the testicular steroidogenesis, we carried out comparative experiments using wild-type and AhR-null male mice that were intraperitoneally administered TCDD. The TCDD administration to...
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