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Article

Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population.

Journal of molecular endocrinology - 1 Aug 2006

Owen Catherine J, Eden James A, Jennings Claire E, Wilson Valerie, Cheetham Tim D, Pearce Simon H S

Abstract excerpt

Regulatory T lymphocytes play a crucial role in modulating potentially self-reactive clones, and dysfunction of this cell type contributes to autoimmune disease. FOXP3 is a critical determinant of CD(4+)CD(25+)T regulatory (T(reg)) cell development and function. The aim of this study was to investigate whether genetic polymorphisms at the FOXP3 locus predispose to autoimmune endocrinopathies. Five single...

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Source

Identifiers

PMID: 16901927
DOI: 10.1677/jme.1.02072

Genes

FOXP3

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Source receipt: pubmed, retrieved 7 Sept 2026.

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