Article
An association study of single nucleotide polymorphisms of the FOXP3 intron-1 and the risk of Psoriasis vulgaris.
Indian journal of biochemistry & biophysics - 1 Feb 2012
Song Qiu-He, Shen Zhu, Xing Xiao-Jing, Yin Rui, Wu Ya-Zhou, You Yi, Guo Hong, Chen Ling, Hao Fei, Bai Yun
Abstract excerpt
Psoriasis vulgaris (PV) is a common autoimmune disease that involves the dysfunction of CD4+CD25+ regulatory T cells. FOXP3 is a key transcription factor in the development and function of CD4+CD25+ regulatory T cells. Previous studies have demonstrated a genetic association between the FOXP3 gene and some autoimmune diseases. To elucidate the association between the FOXP3 gene and the risk of PV, 408 patients...
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