Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p62 Promotes Amino Acid Sensitivity of mTOR Pathway and Hepatic Differentiation in Adult Liver Stem/Progenitor Cells.

Journal of cellular physiology - 1 Aug 2017

Sugiyama Masakazu, Yoshizumi Tomoharu, Yoshida Yoshihiro, Bekki Yuki, Matsumoto Yoshihiro, Yoshiya Shohei, Toshima Takeo, Ikegami Toru, Itoh Shinji, Harimoto Norifumi, Okano Shinji, Soejima Yuji, Shirabe Ken, Maehara Yoshihiko

Abstract excerpt

Autophagy is a homeostatic process regulating turnover of impaired proteins and organelles, and p62 (sequestosome-1, SQSTM1) functions as the autophagic receptor in this process. p62 also functions as a hub for intracellular signaling such as that in the mammalian target of rapamycin (mTOR) pathway. Liver stem/progenitor cells have the potential to differentiate to form hepatocytes or cholangiocytes. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Autophagy-Related Protein 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Separation

Share to Chemical and Drug Induced Liver Injury

Share to Hepatocytes

Share to Microtubule-Associated Proteins

Share to Sequestosome-1 Protein

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 27748507
DOI: 10.1002/jcp.25653

Genes

SQSTM1
ATG5
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p62 Promotes Amino Acid Sensitivity of mTOR Pathway and Hepatic Differentiation in Adult Liver Stem/Progenitor Cells.PMID 27748507Read ↗

The role of autophagy in the metabolism and differentiation of stem cellsSemantic proximity Read ↗

Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathwaySemantic proximity Read ↗

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cellsSemantic proximity Read ↗

Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagySemantic proximity Read ↗

Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy‐Defective Mouse LiverSemantic proximity Read ↗

Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem CellsSemantic proximity Read ↗

Bone mesenchymal stem cells improve cholestatic liver fibrosis by targeting ULK1 to regulate autophagy through PI3K/AKT/mTOR pathwaySemantic proximity Read ↗

Differentiation of glutamatergic neurons from mouse embryonic stem cells requires raptor S6K signaling.Semantic proximity Read ↗

ATF5 inhibits autophagy and the Wnt/β-catenin pathway by upregulating mTOR to suppress the stemness of liver cancer stem cellsSemantic proximity Read ↗

mTORC1/NF-κB axis controls amino acid catabolism by regulating the expression of the key enzymes in human hepatocytesSemantic proximity Read ↗

Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets.Semantic proximity Read ↗

Role of the stearyl-coenzyme A desaturase 1 gene in regulating palmitic acid tolerance of goose primary hepatocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.