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Article

Stabilization of the survival motor neuron protein by ASK1.

FEBS letters - 6 May 2011

Kwon Jeong Eun, Kim Eun Kyung, Choi Eui-Ju

Abstract excerpt

The survival motor neuron (SMN) is a spliceosomal snRNP-interacting protein that was initially identified as a defective molecule in spinal muscular atrophy (SMA). The disease severity of SMA is determined by SMN protein level. Here, we show that apoptosis signal-regulating kinase 1 (ASK1) stabilizes SMN protein by inhibiting SMN poly-ubiquitination, and that the kinase activity of ASK1 is less important than its...

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Identifiers

PMID: 21496457
DOI: 10.1016/j.febslet.2011.04.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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