Article
[The plasmid pEJ6.6 carrying the activated c-Ha-ras-1 oncogene increases the mutation frequency in Chinese hamster cells].
Genetika - 1 Jun 1992
Baron E M, Bobrysheva I V, Varshaver N B
Abstract excerpt
The induction of gene mutations and chromosome aberrations by the plasmid pEJ6.6 carrying the activated c-Ha-ras-1 oncogene from human bladder carcinoma was studied in cultured Chinese hamster cells. Both an increase in the frequency of gene mutations to 6-mercaptopurine resistance and of chromosome aberrations was observed after pEJ6.6 treatment as compared to control series (pBR322). Thus the results of...
Topics
- Animals
- Cell Line
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Mercaptopurine
- Mutation
- Plasmids