Article
Gene mutations in small-cell lung cancer (SCLC): results of a panel of 6 genes in a cohort of Italian patients.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2014
Bordi Paola, Tiseo Marcello, Barbieri Fausto, Bavieri Mario, Sartori Giuliana, Marchetti Antonio, Buttitta Fiamma, Bortesi Beatrice, Ambrosini-Spaltro Andrea, Gnetti Letizia, Silini Enrico Maria, Ardizzoni Andrea, Rossi Giulio
Abstract excerpt
BACKGROUND: No target therapies are presently available in the treatment of small-cell lung cancer (SCLC). We investigated the presence of potentially drugable mutations in the EGFR, c-MET, BRAF, KRAS, PDGFRa and c-KIT genes in a retrospective series of SCLC from 2 Italian Institutions. Correlations with immunohistochemical, clinical and outcome features were evaluated. MATERIALS AND METHODS: Genes were studied...
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