Article
ESR1 and EGF genetic variation in relation to breast cancer risk and survival.
Breast cancer research : BCR - 1 Jan 2008
Einarsdóttir Kristjana, Darabi Hatef, Li Yi, Low Yen Ling, Li Yu Qing, Bonnard Carine, Sjölander Arvid, Czene Kamila, Wedrén Sara, Liu Edison T, Hall Per, Humphreys Keith, Liu Jianjun
Abstract excerpt
INTRODUCTION: Oestrogen exposure is a central factor in the development of breast cancer. Oestrogen receptor alpha (ESR1) is the main mediator of oestrogen effect in breast epithelia and has also been shown to be activated by epidermal growth factor (EGF). We sought to determine if common genetic variation in the ESR1 and EGF genes affects breast cancer risk, tumour characteristics or breast cancer survival....
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