Article
The 161TT genotype in the exon 6 of the peroxisome-proliferator-activated receptor gamma gene is associated with premature acute myocardial infarction and increased lipid peroxidation in habitual heavy smokers.
Clinical science (London, England : 1979) - 1 Nov 2004
Chao Ting-Hsing, Li Yi-Heng, Chen Jyh-Hong, Wu Hua-Lin, Shi Guey-Yueh, Liu Ping-Yen, Tsai Wei-Chuan, Guo How-Ran
Abstract excerpt
PPAR (peroxisome-proliferator-activated receptor) is a nuclear receptor. Activation of PPARgamma by its ligands could modulate gene transcription, thereby leading to multiple anti-atherogenic and fibrinolytic effects. However, the association between the 161T allele in exon 6 of the PPARgamma gene and premature AMI (acute myocardial infarction) is not clear. We recruited 146 patients with premature AMI (onset age...
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