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Article

Association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and risk of rheumatic heart disease.

Japanese heart journal - 1 Nov 2004

Chou Hsiang-Tai, Tsai Chang-Hai, Tsai Fuu-Jen

Abstract excerpt

Scarring and collagen deposition in the valves and destruction of myocytes may result from the combined effects of a smoldering rheumatic process and a constant trauma to the mitral valve or aortic valve by the turbulent flow in rheumatic heart disease (RHD). It has been suggested that angiotensin I-converting enzyme (ACE) may be responsible for the increased valvular fibrosis and calcification in the...

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Source

Identifiers

PMID: 15655270
DOI: 10.1536/jhj.45.949

Genes

RHD
ACE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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