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Article

CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo.

The Journal of experimental medicine - 1 Feb 1999

Maldonado-López R, De Smedt T, Michel P, Godfroid J, Pajak B, Heirman C, Thielemans K, Leo O, Urbain J, Moser M

Abstract excerpt

Cells of the dendritic family display some unique properties that confer to them the capacity to sensitize naive T cells in vitro and in vivo. In the mouse, two subclasses of dendritic cells (DCs) have been described that differ by their CD8alpha expression and their localization in lymphoid orga...

Topics

Animals
Antigen Presentation
CD8 Antigens
Dendritic Cells
Immune Tolerance
Immunologic Memory
Interferon-gamma
Interleukins
Langerhans Cells
Lymphocyte Activation
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Phenotype

T-Lymphocytes, Helper-Inducer

Th1 Cells

Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 9927520
DOI: 10.1084/jem.189.3.587
PMCID: PMC2192907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927520-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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