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Article

Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery.

The Journal of biological chemistry - 10 Sept 2004

Dasgupta Piyali, Betts Vicki, Rastogi Shipra, Joshi Bharat, Morris Mark, Brennan Brenda, Ordonez-Ercan Dalia, Chellappan Srikumar

Abstract excerpt

The retinoblastoma protein Rb has antiproliferative and antiapoptotic functions. Our previous studies have shown that certain apoptotic signals can inactivate Rb via the p38 pathway. Here we show that Rb associates with the apoptosis signal-regulating kinase ASK1 in response to specific apoptotic...

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Identifiers

PMID: 15210709
DOI: 10.1074/jbc.M312273200

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15210709-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery.PMID 15210709Read ↗

Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases.Semantic proximity Read ↗

Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.Semantic proximity Read ↗

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.Semantic proximity Read ↗

JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.Semantic proximity Read ↗

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.Semantic proximity Read ↗

Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.Semantic proximity Read ↗

Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.Semantic proximity Read ↗

Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.Semantic proximity Read ↗

An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.Semantic proximity Read ↗

Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.Semantic proximity Read ↗

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.Semantic proximity Read ↗

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death.Semantic proximity Read ↗

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