Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.

The Journal of biological chemistry - 18 Mar 2005

Lieman Jonathan H, Worley Lori A, Harbour J William

Abstract excerpt

Molecular hardwiring of the cell cycle to the apoptotic machinery is a critical tumor suppressor mechanism for eliminating hyperproliferative cells. Deregulation of the Rb-E2F repressor complex by genetic deletion or functional inhibition of Rb triggers apoptosis through both the intrinsic (caspase-9 mediated) and extrinsic (caspase-8 mediated) death pathways. Induction of the intrinsic pathway has been studied...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factors
Share to Apoptotic Protease-Activating Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 8

Share to Caspase 9

Share to E2F Transcription Factors

Share to Focal Adhesion Kinase 1

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Retinoblastoma Protein

Source

Identifiers

PMID: 15640164
DOI: 10.1074/jbc.M409371200

Genes

APAF1
CASP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.PMID 15640164Read ↗

Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases.Semantic proximity Read ↗

Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2Semantic proximity Read ↗

Emerging Links between E2F Control and Mitochondrial FunctionSemantic proximity Read ↗

E2F1 pathways to apoptosisSemantic proximity Read ↗

S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.Semantic proximity Read ↗

Egr1 mediates p53-independent c-Myc–induced apoptosis via a noncanonical ARF-dependent transcriptional mechanismSemantic proximity Read ↗

Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates ApoptosisSemantic proximity Read ↗

Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery.Semantic proximity Read ↗

Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation.Semantic proximity Read ↗

A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis.Semantic proximity Read ↗

E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways.Semantic proximity Read ↗

pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.