Article
The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas.
Molecular human reproduction - 1 Aug 2004
Oudejans Cees B M, Mulders Joyce, Lachmeijer Augusta M A, van Dijk Marie, Könst Andrea A M, Westerman Bart A, van Wijk Inge J, Leegwater Peter A J, Kato Hidenori D, Matsuda Takao, Wake Norio, Dekker Gustaaf A, Pals Gerard, ten Kate Leo P, Blankenstein Marinus A
Abstract excerpt
By affected sib-pair linkage analysis of 24 families with pre-eclampsia, we confirm a susceptibility locus on chromosome 10q22.1 in Dutch females: a multipoint non-parametric linkage score of 3.6 near marker D10S1432 was obtained. Haplotype analysis showed a parent-of-origin effect: maximal allele sharing in the affected sibs was found for maternally derived alleles in all families, but not for the paternally...
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