Article
A Family Based Study of Carbon Monoxide and Nitric Oxide Signalling Genes and Preeclampsia.
Paediatric and perinatal epidemiology - 1 Jan 2018
Bauer Anna E, Avery Christy L, Shi Min, Weinberg Clarice R, Olshan Andrew F, Harmon Quaker E, Luo Jingchun, Yang Jenny, Manuck Tracy A, Wu Michael C, Williams Nicholas, McGinnis Ralph, Morgan Linda, Klungsøyr Kari, Trogstad Lill, Magnus Per, Engel Stephanie M
Abstract excerpt
BACKGROUND: Preeclampsia is thought to originate during placentation, with incomplete remodelling and perfusion of the spiral arteries leading to reduced placental vascular capacity. Nitric oxide (NO) and carbon monoxide (CO) are powerful vasodilators that play a role in the placental vascular system. Although family clustering of preeclampsia has been observed, the existing genetic literature is limited by a...
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