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Article

Differential methylation of STOX1 in human placenta.

Epigenetics - 1 Jan 2000

van Dijk Marie, Drewlo Sascha, Oudejans Cees B M

Abstract excerpt

The 10q22 chromosomal region with genomic linkage to pre-eclampsia in Dutch females shows a parent-of-origin effect with maternal transmission of the Y153H susceptibility allele of the STOX1 gene. Although the CpG island within the STOX1 promoter region shows no differential methylation, this study describes the identification of a differentially methylated region (DMR) in intron 1 of the STOX1 gene. Methylation...

Topics

Alleles
Carrier Proteins
CpG Islands
DNA Methylation
Female
Gene Expression Regulation
Genetic Linkage
Genetic Predisposition to Disease
Homozygote
Humans
Introns
Netherlands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pre-Eclampsia

Pregnancy

Trophoblasts

Source

Identifiers

PMID: 20716964
DOI: 10.4161/epi.5.8.13084

Genes

STOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Differential methylation of STOX1 in human placenta.PMID 20716964Read ↗

STOX1: Key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation.Semantic proximity Read ↗

Association of <em>STOX1</em> Maternal and Fetal Polymorphisms with Hypertensive Disorders of Pregnancy: Preliminary Evidence for a Parent-of-Origin Effect and Maternal-Fetal Genotypic InteractionSemantic proximity Read ↗

Short communication: STOX1 gene in pre‐eclampsia and intrauterine growth restrictionSemantic proximity Read ↗

The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.Semantic proximity Read ↗

Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.Semantic proximity Read ↗

Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia.Semantic proximity Read ↗

Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 IsoformsSemantic proximity Read ↗

STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study.Semantic proximity Read ↗

Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.Semantic proximity Read ↗

STOX1 Overexpression in Choriocarcinoma Cells Mimics Transcriptional Alterations Observed in Preeclamptic PlacentasSemantic proximity Read ↗

STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defectsSemantic proximity Read ↗

Noncoding RNA-regulated gain-of-function of STOX2 in Finnish pre-eclamptic families.Semantic proximity Read ↗

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