Article
A genetic basis for the "Adonis" phenotype of low adiposity and strong bones.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2004
Johnson Geoffrey B, Riggs B Lawrence, Platt Jeffrey L
Abstract excerpt
Toll receptors in Drosophila contribute to host defense and establish the body plan. Mammalian homologues of Toll, the Toll-like receptors (TLRs), are thought to function only in host defense. Here, we report that mice harboring mutations in TLR4 or in CD14, a co-receptor for TLR4, have an "ideal" body plan consisting of increased bone mineral content, density, and size as well as decreased body fat. These mutant...
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