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Article

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding.

Molecular and cellular neurosciences - 1 Jun 2004

Liu Zhe, Patel Kalpana, Schmidt Hannes, Andrews William, Pini Adrian, Sundaresan Vasi

Abstract excerpt

Robo, the receptor for the midline repellent Slit, is a member of the cell adhesion molecule (CAM) Ig superfamily. We have recently demonstrated that members of the Robo family (Robo1 and Robo2) interact homophilically and heterophilically, thereby functioning to promote neurite outgrowth. Here, we describe a series of in vitro experiments to dissect the Robo ligand-interacting domains by deleting specific...

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Source

Identifiers

PMID: 15207848
DOI: 10.1016/j.mcn.2004.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding.PMID 15207848Read ↗

In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.Semantic proximity Read ↗

Repellent signaling by Slit requires the leucine-rich repeats.Semantic proximity Read ↗

Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain.Semantic proximity Read ↗

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularizationSemantic proximity Read ↗

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments.Semantic proximity Read ↗

Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion.Semantic proximity Read ↗

Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea.Semantic proximity Read ↗

Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.Semantic proximity Read ↗

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.Semantic proximity Read ↗

Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.Semantic proximity Read ↗

Slit is the midline repellent for the robo receptor in Drosophila.Semantic proximity Read ↗

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