Article
Gene expression analysis of the lung following paraquat administration in rats using DNA microarray.
The Journal of toxicological sciences - 1 May 2004
Satomi Yoshihide, Tsuchiya Wakana, Mihara Keiko, Ota Mikio, Kasahara Yoshinori, Akahori Fumiaki
Abstract excerpt
Gene expression changes in the lungs induced by paraquat (PQ) administration were studied in rats using DNA microarrays that were detectable for 1,090 genes per DNA microarray. The rats were subjected to subacute PQ exposure (7 mg/kg, s.c., daily for eight administrations). Two days after the final administration, the rats were divided into two groups. Group 1 experienced significant body weight loss and...
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