Article
Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone.
Free radical biology & medicine - 15 Jul 2004
de Castro Edouard, Hegi de Castro Sarah, Johnson Thomas E
Abstract excerpt
The accumulation of molecular damage from attack by reactive oxygen species is one cause of aging. Therefore, some mutant organisms showing increased resistance to reactive oxygen species should live longer. We show that selection for Caenorhabditis elegans mutants that are resistant to juglone, a reactive oxygen species-generating compound, leads to the identification of long-lived mutants. Indeed, four of six...
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