Article
Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP Maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs.
American journal of human genetics - 1 Aug 2004
Kamatani Naoyuki, Sekine Akihiro, Kitamoto Takuya, Iida Aritoshi, Saito Susumu, Kogame Akifumi, Inoue Eisuke, Kawamoto Manabu, Harigai Masayoshi, Nakamura Yusuke
Abstract excerpt
To optimize the strategies for population-based pharmacogenetic studies, we extensively analyzed single-nucleotide polymorphisms (SNPs) and haplotypes in 199 drug-related genes, through use of 4,190 SNPs in 752 control subjects. Drug-related genes, like other genes, have a haplotype-block structure, and a few haplotype-tagging SNPs (htSNPs) could represent most of the major haplotypes constructed with common SNPs...
Topics
- Computational Biology
- Gene Frequency
- Haplotypes
- Humans
- Pharmacokinetics
- Polymorphism, Single Nucleotide